Journal of Bioinformatics and Systems Biology covers the major topics like 

• Biomedical image processing, modelling and simulation
• Bio-ontology and data mining, DNA assembly, clustering, mapping
• Computational genomics/proteomics
• Databases, bio-grid, system biology
• Development of algorithmic, mathematical, statistical, modeling
• General in health and medicine
• Parallel algorithms/architectures, computational structural biology
• Phylogeny reconstruction algorithms, physiome, protein structure prediction
• Sequence assembly, search, alignment
• Signal processing
• Signalling/computational biomedical data engineering
• Silico technology
• Simulation, data mining, and computational techniques