Source	Sex	Age at diagnosis	Clinical mani-festations	*Lymphocyte count at diag-nosis (10^9/L)**	Clonality	Immuno-phenotypic markers	Laboratory findings	Associated auto-immune or hema-tological disease	Treatment under-gone for SS and LGL
Molad et al. 2001	F	65	Arthralgia, keratoc-onjunctivitis sicca, fatigue, weight loss	2.9 (maximum value reached: 4.5)	Not determined	CD8+, CD57+, CD16+	RF +, ANA +, anti-Ro antibodies +	None reported	Cyclosporin A
Molad et al. 2001	F	70	Neutropenia, xero-pthlamia, xerostom-ia, fatigue, arthritis	6.3	Not determined	CD8+, CD57+/-	RF +, ANA +	Hashimoto thyroiditis	Not reported
Ergas et al. 2002	F	30	Pure red cell aplasia, amegak-aryocytic throm-bo-cytopenic pu-rpura, xeropthal-mia, xerostomia	2.5	Clonal re-arrangement of the TCR gene	CD8+, CD45R+	None reported	Hashimoto tyroiditis, premature ovarian failure	Azathioprine, blood and platelet transfu-sions, high dose in-travenous immuneo-globulin, cyclospori-n A, methotrexate, cyclophosphamide
Friedman et al. 2006	F	44	Pure red cell aplasia, agranulocytosis, immmune thrombo-cytopenia	7.8	Clonal rearrangement of the TCR gene in all but one patient	CD8+	None reported	None reported	Not reported
Friedman et al. 2006	F	68	None reported	4.2		CD4+, CD57+	Antithyroid	Polycystic ovarian syndrome, anemia of chronic disease	Not reported
Friedman et al. 2006	F	68	None reported	4.2		CD4+, CD57+	antibodies +	Polycystic ovarian syndrome, anemia of chronic disease	Not reported
Friedman et al. 2006	F	64	None reported	4.1		CD4+	Antithyroid	Angioneurotic edema	Not reported
Friedman et al. 2006	F	64	None reported	4.1		CD4+	antibodies +	Angioneurotic edema	Not reported
Friedman et al. 2006	F	72	None reported	2.8		CD8+, CD57+	None reported	Diabetes, anemia of chronic disease	Not reported
Friedman et al. 2006	F	73	None reported	3.8		CD8+, CD56+	None reported	CREST syndrome	Not reported
Friedman et al. 2006	F	75	None reported	3.1		CD4+	None reported	Hashimoto thyroiditis	Not reported
Friedman et al. 2006	F	66	Agranulocytosis, immune thrombocy-topenia	4.3		CD8+	None reported	Hyperparathyroidism	Not reported
Friedman et al. 2006	F	64	Leukopenia	1		CD8+	None reported	Hashimoto thyroiditis, vitiligo	Not reported
Friedman et al. 2006	F	61	Agranulocytosis	1.2		CD8+	None reported	Diabetes	Not reported
Friedman et al. 2006	F	43	Agranulocytosis, Raynaud's phenomenon	0.8		CD8+	Monoclonal IgG k component	None reported	Not reported
Friedman et al. 2006	F	66	None reported	2.3		CD4+	Antithyroid	None reported	Not reported
Friedman et al. 2006	F	66	None reported	2.3		CD4+	antibodies +	None reported	Not reported
Friedman et al. 2006	F	63	None reported	9.6		CD8+, CD57+	None reported	Hashimoto thyroiditis	Not reported
Friedman et al. 2006	F	71	None reported	7.3		CD8+, CD56+	None reported	None reported	Not reported
Franco et al. 2010	F	73	Neutropenia, fever, splenomegaly, cerv-ical lymphadenopat-hy, xerofthalmia, xerostomia	1.7	Clonal rear-angement of the TCR gene	CD8+, CD57+, CD56-	Polyclonal hyp-ergammaglobulinemia, monocl-onal IgA lamb-da component,	Chronic disease related anemia	Methotrexate
Franco et al. 2010	F	73		1.7	Clonal rear-angement of the TCR gene	CD8+, CD57+, CD56-	RF +, ANA +	Chronic disease related anemia	Methotrexate
Baber et al. 2019	F	55	Arthralgia, interstitial nephritis, neutropenia	8.5	Oligoclonal TCR beta chain rear-rangement	CD8+	Anti-SSA antib-odies and RF +	Lymphoma	Hydroxy-chloroqui-ne, R-bendamustine, methotrexate, G-CSF
Baber et al. 2019	M	62	Neutropenia	3.1	Oligoclonal TCR beta chain rear-rangement	CD8+	Anti-SSA and anti-SSB antib-odies and RF +	None reported	None
Baber et al. 2019	F	82	Autoimmune thrombo-cytopenia, neutropenia	2.4	Not determined	CD8+	None reported	None reported	None
Baber et al. 2019	F	80	Arthralgia, neutropenia	7.3	Not determined	NK cells	Anti-SSA antibodies +	None reported	None
Baber et al. 2019	F	80	Polyartritis, periphe-ral neuropathy, my-ositis, neutropenia	0.9	Oligoclonal TCR beta chain rearran-gement	CD8+	RF +	None reported	Prednisone, methotrexate, rituximab
Baber et al. 2019	F	52	Arthralgia, interstitial lung disease, glomerulo-nephritis, cryo-globulinemia, neutropenia	0.9	TCR beta cha-in rearrange-ent monoclon-al in CD8+ T cells and oli-goclonal in CD4+ T cells	CD8+	RF +	None reported	Prednisone, rituximab
Baber et al. 2019	F	67	Arthralgia, cryo-globulinemia, neutropenia	3.3	Monoclonal TCR beta chain rearra-ngement	CD8+	RF +	Pulmonary AL amyloidosis	Rituximab
Baber et al. 2019	F	67	Peripheral neuropathy, cryglobulinemia, neutropenia	1	Oligoclonal TCR beta chain rear-angement	CD8+, CD57+/-, CD45RA+	Anti-SSA and anti-SSB antibodies and RF +	None reported	Rituximab
Tavarozzi et al. 2020	F	39	Xerophtalmia, xerostomia, anemia, thrombo-cytopenia	8.2	Monoclonal TCR beta chain rear-angement	CD8+, CD57+/-, CD45RA+	ANA, ENA, and anti-SSA antibodies +	None reported	Hydroxy-chloroquine